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Andarine is an orally active partial agonist of the androgen receptor (AR). In intact male rats, 0.5 mg S4 daily was shown to reduce prostate weight to 79.4%, and non-significantly increased levator ani muscle weight. In castrated male rats, this dose restored only 32.5% prostate weight, but 101% levator ani muscle weight. This suggests that s4 is able to competitively block binding of dihydrotestosterone to its receptor targets in the prostate gland, but its partial agonist actions at the AR prevent the side effects associated with the antiandrogens traditionally used for the treatment of BPH
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